Research Article

Ebrahim Abolmagd,Fathy M Salama, Khalid A Attia, Ahmed A Abouserie, Ahmed El Olemy

Abstract: Atomic absorption spectrometric method has been developed and validated for direct determination of amoxicillin sodium in its pure and pharmaceutical dosage forms based on its sodium content at ?589 nm. The developed method was found to be time and cost saving and has no tedious or complex procedures. The developed method is very sensitive regarding LOD (0.025ppm of sodium equivalent to 0.423?g mL-1), LOQ (0.076ppm of sodium equivalent to 1.282?g mL-1) and linearity range (0.2-1ppm of sodium) equivalent to (3.37-16.84 ?g mL-1). The accuracy of the method was further assessed by application of standard addition technique and very satisfactory results were obtained. The results obtained by the proposed method were compared by statistical measures to reference method and there were no significant difference between the developed method and the reference method regarding the accuracy and precision. The developed method was validated according to ICH guidelines and the results were satisfactory.

Published Date: 12 Jun 2018

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