Abstract: Xylene is used as a solvent with wide areas of application. The mechanism of xylene induced injuries has not been well documented. It has not been reported whether xylene could result in cell apoptosis by DNA modification. Our results showed that xylene could significantly suppress the methylation of Bax promoter in HK-2 cells. Xylene induced the increase of Bax mRNA in a dose dependent manner. Bax protein expression was significantly increased while the level of Bcl-2 was not affected. Xylene could significantly induce the apoptosis of HK-2 cells. Our results suggested that xylene could cause apoptosis of HK-2 cells by suppressing DNA methylation of Bax promoter.
Published Date: 06 Dec 2017